Brain abscess is a relatively rare disease. Despite advances in its diagnosis through the use of neuro-imaging methods and the comparatively better prognosis in the antibiotic age, this disease is still a challenge for medical specialists. We present a case of a 58-year-old woman developing a large brain abscess in the left frontal and parietal lobe, after a poorly treated respiratory infection. The case is characterized by the size of the abscess. After the diagnostic procedures, conservative and surgical treatment, a very good recovery was achieved. The patient was discharged without neurological deficit.